The Ligand Activated Therapy, or LAT, platform, is a registered trademark of KemPharm.
IR d-MPH is rapidly absorbed.1,3
SDX travels to the lower GI tract,
where it undergoes bioactivation
and is converted to d-MPH.1,4,5
The normal metabolic process
continuously separates the d-MPH
from the inactive ligand.1,4,5
The continuous conversion of d-MPH
is intended to provide appropriate
levels of active drug throughout the
day with a gradual offset.1,3-5
Mean plasma concentrations of d-MPH measured throughout the day1,a
aFollowing a single dose of AZSTARYS in healthy adults under fasted conditions. Mean plasma concentrations continued to gradually decline through 72 hours post dose.1
d-MPH, dexmethylphenidate; GI, gastrointestinal; IR, immediate-release; SDX, serdexmethylphenidate.
References: 1. AZSTARYS. Prescribing information.
Corium Inc; 2021. 2. Mickle T, Guenther S, Chi G,
inventors; KemPharm, Inc, assignee. Methylphenidate-
prodrugs, processes of
making and using the same.
U.S. patent 10,584,113. March 10, 2020. 3. Childress
AC, Komolova M, Sallee FR. An update on the
pharmacokinetic considerations in the treatment of
ADHD with long-acting methylphenidate and
amphetamine formulations. Expert Opin Drug Metab
Toxicol. 2019;15(11):937-974.
doi:10.1080/17425255.2019.1675636 4. Patrick
KS,
Radke JL, Raymond JR, et al. Drug regimen
individualization for attention-deficit/hyperactivity
disorder: guidance for methylphenidate and
dexmethylphenidate formulations.
Pharmacotherapy.
2019;39(6):677-688. doi:10.1002/phar.2190 5. Gudin JA, Nalamachu SR. An overview of prodrug technology and its application for developing abuse-deterrent
opioids. Postgrad Med. 2016;128(1):97-105. doi:10.1080/00325481.2016.1126186
AZSTARYS is a central nervous system
(CNS) stimulant indicated for the
treatment of Attention Deficit
Hyperactivity Disorder
(ADHD) in
patients 6 years and older.
WARNING: ABUSE AND DEPENDENCE
Please click here for Full
Prescribing Information,
including Boxed WARNING.
AZSTARYS is a central nervous system
(CNS) stimulant indicated for the
treatment of Attention Deficit
Hyperactivity Disorder (ADHD) in
patients 6 years and older.
WARNING: ABUSE AND DEPENDENCE